Please use this identifier to cite or link to this item: https://dspace.crs4.it/jspui/handle/1138/49
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dc.contributor.authorZelic, Renataen_US
dc.contributor.authorgiunchi, francescaen_US
dc.contributor.authorFridfeldt, Jonnaen_US
dc.contributor.authorCarlsson, Jessicaen_US
dc.contributor.authorDavidsson, Sabinaen_US
dc.contributor.authorLianas, Lucaen_US
dc.contributor.authorMascia, Ceciliaen_US
dc.contributor.authorZUGNA, DANIELAen_US
dc.contributor.authorMolinaro, Lucaen_US
dc.contributor.authorVincent, Per Henriken_US
dc.contributor.authorZanetti, Gianluigien_US
dc.contributor.authorAndrén, Oveen_US
dc.contributor.authorrichiardi, lorenzoen_US
dc.contributor.authorAkre, Olofen_US
dc.contributor.authorFiorentino, Michelangeloen_US
dc.contributor.authorPettersson, Andreasen_US
dc.contributor.editorEhrenstein, Veraen_US
dc.date.accessioned2022-09-23T05:58:21Z-
dc.date.available2022-09-23T05:58:21Z-
dc.date.issued2022-01-18-
dc.identifier.urihttps://dspace.crs4.it/jspui/handle/1138/49-
dc.description.abstractBackground The International Society of Urological Pathology (ISUP) revised the Gleason system in 2005 and 2014. The impact of these changes on prostate cancer (PCa) prognostication remains unclear. Objective To evaluate if the ISUP 2014 Gleason score (GS) predicts PCa death better than the pre-2005 GS, and if additional histopathological information can further improve PCa death prediction. Patients and Methods We conducted a case–control study nested among men in the National Prostate Cancer Register of Sweden diagnosed with non-metastatic PCa 1998–2015. We included 369 men who died from PCa (cases) and 369 men who did not (controls). Two uro-pathologists centrally re-reviewed biopsy ISUP 2014 Gleason grading, poorly formed glands, cribriform pattern, comedonecrosis, perineural invasion, intraductal, ductal and mucinous carcinoma, percentage Gleason 4, inflammation, high-grade prostatic intraepithelial neoplasia (HGPIN) and post-atrophic hyperplasia. Pre-2005 GS was back-transformed using i) information on cribriform pattern and/or poorly formed glands and ii) the diagnostic GS from the registry. Models were developed using Firth logistic regression and compared in terms of discrimination (AUC). Results The ISUP 2014 GS (AUC = 0.808) performed better than the pre-2005 GS when back-transformed using only cribriform pattern (AUC = 0.785) or both cribriform and poorly formed glands (AUC = 0.792), but not when back-transformed using only poorly formed glands (AUC = 0.800). Similarly, the ISUP 2014 GS performed better than the diagnostic GS (AUC = 0.808 vs 0.781). Comedonecrosis (AUC = 0.811), HGPIN (AUC = 0.810) and number of cores with ≥50% cancer (AUC = 0.810) predicted PCa death independently of the ISUP 2014 GS. Conclusion The Gleason Grading revisions have improved PCa death prediction, likely due to classifying cribriform patterns, rather than poorly formed glands, as Gleason 4. Comedonecrosis, HGPIN and number of cores with ≥50% cancer further improve PCa death discrimination slightly.en_US
dc.language.isoenen_US
dc.publisherDove Pressen_US
dc.relationDeep-Learning and HPC to Boost Biomedical Applications for Healthen_US
dc.relationDIFRAen_US
dc.relation.ispartofClinical Epidemiologyen_US
dc.subjectprostate canceren_US
dc.subjectprognosisen_US
dc.subjectprognostic markersen_US
dc.subjectGleason scoreen_US
dc.subjectvirtual microscopyen_US
dc.subjecthistopathologyen_US
dc.titlePrognostic Utility of the Gleason Grading System Revisions and Histopathological Factors Beyond Gleason Gradeen_US
dc.typejournal articleen_US
dc.identifier.doi10.2147/CLEP.S339140-
dc.contributor.affiliationClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Swedenen_US
dc.contributor.affiliationPathology Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italyen_US
dc.contributor.affiliationDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Swedenen_US
dc.contributor.affiliationDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Swedenen_US
dc.contributor.affiliationDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Swedenen_US
dc.contributor.affiliationData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italyen_US
dc.contributor.affiliationData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italyen_US
dc.contributor.affiliationCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italyen_US
dc.contributor.affiliationDivision of Pathology, A.O. Città della Salute e della Scienza Hospital, Turin, Italyen_US
dc.contributor.affiliationDepartment of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, SE-17176 Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden KI, Swedenen_US
dc.contributor.affiliationData-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italyen_US
dc.contributor.affiliationDepartment of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Swedenen_US
dc.contributor.affiliationCancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italyen_US
dc.contributor.affiliationDepartment of Clinical Pathology and Cancer Diagnostics, Karolinska University Hospital, SE-17176 Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17176 Stockholm, Sweden KI, Swedenen_US
dc.contributor.affiliationPathology Service, Maggiore Hospital, University of Bologna, Bologna, Italyen_US
dc.contributor.affiliationClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Swedenen_US
dc.contributor.editoraffiliationDepartment of Clinical Epidemiology, Aarhus University, Denmarken_US
dc.relation.issn1179-1349en_US
dc.description.volume2022:14en_US
dc.description.startpage59en_US
dc.description.endpage70en_US
dc.relation.grantno825111en_US
dc.relation.grantnoPOR FESR 2014-2020en_US
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.grantfulltextopen-
item.openairetypejournal article-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.orcid0000-0002-8842-5964-
crisitem.author.orcid0000-0002-8952-725X-
crisitem.author.orcid0000-0002-3750-3029-
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